According to Indiana Historical Society, “In the early 1880s Dr. Franklin L. Miles began bottling and selling “Restorative Nervine,” which he prescribed for a variety of illnesses including nervous exhaustion, headaches, insomnia, backaches, epilepsy, and miscellaneous pains and spasms. The bromide sedative syrup was a precursor to modern tranquilizers. Miles had reason enough for nervous disorders in his own life. His mother and sister died in an epidemic when he was young, leaving him to be raised by relatives in Elkhart; his father, a fortune-seeker in California and Hawaii, was absent much of his youth; and his first wife died eight years after their marriage, leaving him with three young children. But the young Miles took the $5,000 he inherited upon his father’s death and financed an extended program of academic study, moving fitfully through assorted eastern and Midwestern schools and studying widely in law and medicine. Miles had a broad-ranging mind, writing prolifically on popular medical topics as well as expounding views on scientific child rearing and the dangers of monopoly. In addition to caring for patients and writing, he became interested in the relation of the brain and the nervous system to general health; his medications were an outgrowth of this concern.
In 1884 Miles founded the Dr. Miles Medical Company to market his medications (ranging from his Restorative Nervine to tonics, blood purifiers, and liver pills). The Dr. Miles Medical Company invested heavily in advertising; the advertising budget was $100,000 as early as 1893. The company printed a huge amount of advertising material on its own presses, including a wide variety of colorful almanacs sent to rural customers, calendars distributed by retail druggists, and a Little Book series on health and housekeeping topics. The material combined useful information with product promotion. Alka-Seltzer, a compound of aspirin, citric acid, and sodium bicarbonate that was an effective and fast-working remedy for colds, aches, and upset stomachs, is testament to the firm’s marketing prowess. In 1932 the company became Dr. Miles Laboratories, shortened to Miles Laboratories three years later. The company expanded and diversified over the years, opening plants overseas and purchasing subsidiaries that produced everything from S.O.S. soap pads for the kitchen to citric acid, enzymes, and medical supplies. In 1978 Bayer AG, an international chemical and health care company based in Leverkusen, Germany, acquired Miles Laboratories for $253 million.”